Solid-phase synthesis of multivalent glycoconjugates on a DNA synthesizer

Michael Dubber, Jean Frechet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Carbohydrate - oligonucleotide conjugates and glycodendrimers were synthesized utilizing a DNA synthesizer. The synthesis of multivalent glycoconjugates on solid-phase allows custom tailoring of their structure to the requirements of biological assays within hours, as opposed to traditional approaches that require weeks or months of work in the laboratory. Therefore it will become much easier to investigate carbohydrate - protein interactions and optimize for objectives such as the receptor-mediated targeting of antisense oligonucleotides.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalBioconjugate Chemistry
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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