Siliceous mesocellular foam for high-performance liquid chromatography: Effect of morphology and pore structure

Yu Han, Su Seong Lee*, Jackie Y. Ying

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Spherical siliceous mesocellular foam (MCF) particles with an average particle size of 4.8μm have been successfully prepared. These spherical particles were tailored in pore sizes and surface areas. They were functionalized with C8 or C18 groups, and applied towards reversed phase high-performance liquid chromatography (HPLC) column separations. Their high surface areas gave rise to very good retention characteristics, as illustrated in the separation of a series of alkylbenzene solutes with increasing chain length. The highly interconnected porous structure and ultralarge pore size of MCF allowed the columns to be used at high flow rates without much loss in column efficiency. The column efficiency and peak symmetry were further improved by eliminating the micropores of the stationary phase. The reversed phase column packed with C18-modified spherical MCF particles provided for excellent separation of different deoxynucleosides, illustrating the broad applicability of these materials due to their controlled pore size.

Original languageEnglish (US)
Pages (from-to)4337-4343
Number of pages7
JournalJournal of Chromatography A
Volume1217
Issue number26
DOIs
StatePublished - Jun 1 2010

Keywords

  • High-performance liquid chromatography
  • Mesoporous silica
  • Morphology
  • Reversed phase column

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Biochemistry

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