Short α/β-peptides as catalysts for intra- and intermolecular aldol reactions

Valerio D Elia, Hans Zwicknagl, Oliver Reiser*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

(Chemical Equation Presented) Short α/β-peptides, containing conformationally restricted cis-β-aminocyclopropylcarboxylic acid units as turn-inducing elements, have been found to be efficient catalysts for inter-and intramolecular aldol reactions. The tripeptide H-(L)-Pro-▲-(L)-Pro-OH was identified to perform especially well in homogeneous and heterogeneous aqueous solutions as well as in organic solvents.

Original languageEnglish (US)
Pages (from-to)3262-3265
Number of pages4
JournalJournal of Organic Chemistry
Volume73
Issue number8
DOIs
StatePublished - Apr 18 2008

ASJC Scopus subject areas

  • Organic Chemistry

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