Separation of hydrophilic oligomers and polymers using monodisperse poly(2,3-dihydroxypropyl methacrylate-co-ethylene dimethacrylate) beads via normal-phase and hydrophilic-interaction hplc

František Švec*, Miroslav Petro, Jean Frechet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Microparticulate, monosized, and macroporous poly(2,3-dihydroxypropyl methacrylate-co-ethylene dimethacrylate) beads have been used as a stationary phase for HPLC separations of hydrophilic oligomers and polymers. Homogeneous coverage of the sorbent surface with a large number of chemically equivalent diol functionalities affords suitable retentivity in both normal-phase and hydrophilic-interaction chromatographic modes and enables the separations of water-soluble oligomers and polymers. Chromatographic properties of this stationary phase are demonstrated on a variety of separations of poly(oxyalkylene)s, polyvinylpyrrolidones, and polysaccharides. Keywords: Normal-phase HPLC; Hydrophilic-interaction chromatography; Stationary phases; Polymeric-diol beads; Poly(glycidyl methacrylate-co-ethylene dimethacrylate); Poly(2,3-dihydroxypropyl methacrylate); Poly(oxyalkylene)s; Polysaccharides; Cyclodextrins; Polymers.

Original languageEnglish (US)
Pages (from-to)1047-1060
Number of pages14
JournalCollection of Czechoslovak Chemical Communications
Volume66
Issue number7
DOIs
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Chemistry(all)

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