Separation of enantiomers by capillary electrochromatography

Michael Lämmerhofer, Frantisek Svec, Jean Frechet, Wolfgang Lindner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

The current popularity of capillary electrochromatography (CEC) has led to an increasing number of studies on the development and evaluation of enantioselective CEC systems. These studies clearly demonstrate that the most prominent advantage of electrically driven separation methods, the vastly increased column efficiency as compared to pressure-driven chromatography, can also be experimentally achieved for the separations of enantiomers. In analogy to high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE), several approaches have been used. The addition of a chiral selector to the mobile phase is the simplest method. Less erroneous and more elegant approaches are those that use open-tubular, conventional packed, and monolithic columns containing chiral stationary phases that stereoselectively interact with enantiomers. This review evaluates the new techniques and compares them to enantioselective HPLC and CE. Further, it describes the various concepts of enantioselective CEC and focuses on the current 'state-of-the-art' column technology. (C) 2000 Published by Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)676-698
Number of pages23
JournalTrAC - Trends in Analytical Chemistry
Volume19
Issue number11
DOIs
StatePublished - Nov 28 2000

Keywords

  • Capillary electrochromatography
  • Chiral stationary phases
  • Enantioselective open-tubular electrochromatography
  • Monolithic chiral stationary phases
  • Packed capillary columns

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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