Self-optimizing reactor systems: Algorithms, on-line analytics, setups, and strategies for accelerating continuous flow process optimization

David C. Fabry, Erli Sugiono, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


This review provides an overview of recent developments in the area of continuous flow process optimization by employing self-optimizing reactor systems. Although only few reactor concepts have been realized to date, impressive progress has been made, which now allows fully automated reaction optimization without the need of human interactions.

Original languageEnglish (US)
Pages (from-to)341-350
Number of pages10
JournalIsrael Journal of Chemistry
Issue number4
StatePublished - 2014
Externally publishedYes


  • asymmetric reduction
  • cross-coupling
  • hydrogenation
  • microreactor
  • Suzuki reaction

ASJC Scopus subject areas

  • Chemistry(all)

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