Self-Assembled Metal–Organic Complexes for Thermally Reversible Permeabilization of Cell Membranes

Safa'a Al-Rehili, Mram Z. Alyami, Yang Zhang, Basem Moosa, Peng Yang, Kholod Alamoudi, Siba Alharbi, Ohoud Alharbi, Rachid Sougrat, Abdulaziz AlMalik, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

Abstract

Natural and synthetic membrane active molecules increase the permeability of cell membranes. This can help cells combat multidrug efflux pumps as well as improve signaling and transfection. In this work, thermoresponsive metal–organic complexes (MOCs) have been constructed to transport cell impermeable cargo across the membrane through a pore-aiding assembly. These MOCs can be reversibly controlled as they collapse when the temperature is increased and are simultaneously regenerated when the system is cooled down to room temperature. These ON/OFF molecular valves can be potentially used to overcome multidrug resistance (MDR) in cancer cells and as building blocks for artificial cells.
Original languageEnglish (US)
Pages (from-to)970-974
Number of pages5
JournalACS Applied Bio Materials
Volume2
Issue number3
DOIs
StatePublished - Feb 6 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by King Abdullah University of Science and Technology (KAUST). Scheme 1 and the TOC illustration were produced by Xavier Pita, scientific illustrator at King Abdullah University of Science and Technology (KAUST).

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