Selective benzylic Csp3–H bond activations mediated by a phosphorus–nitrogen PN3P-nickel complex

Kuo-Wei Huang, Changguang Yao, Tonghuan Zhang, Theo Goncalves

Research output: Contribution to journalArticlepeer-review

Abstract

In contrast to the typical Csp2−H activation, a PN3P-Nickel complex chemoselectively cleaved the benzylic Csp3–H bond of toluene in the presence of KHMDS, presumably via an in situ generated potassium benzyl intermediate. Under similar conditions, CO underwent deoxygenation to afford the corresponding nickel cyano complex, and ethylbenzene was dehydrogenated to give styrene and a nickel hydride compound. 2,6-xylyl isocyanide was transformed into an unprecedented indolyl complex, likely by trapping the activated benzyl species with a isocyanide moiety.
Original languageEnglish (US)
JournalChemical Communications
DOIs
StatePublished - 2022

ASJC Scopus subject areas

  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Ceramics and Composites
  • Chemistry(all)
  • Catalysis
  • Electronic, Optical and Magnetic Materials

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