Scalable, incremental learning with MapReduce parallelization for cell detection in high-resolution 3D microscopy data

Chul Sung, Jongwook Woo, Matthew Goodman, Todd Huffman, Yoonsuck Choe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Accurate estimation of neuronal count and distribution is central to the understanding of the organization and layout of cortical maps in the brain, and changes in the cell population induced by brain disorders. High-throughput 3D microscopy techniques such as Knife-Edge Scanning Microscopy (KESM) are enabling whole-brain survey of neuronal distributions. Data from such techniques pose serious challenges to quantitative analysis due to the massive, growing, and sparsely labeled nature of the data. In this paper, we present a scalable, incremental learning algorithm for cell body detection that can address these issues. Our algorithm is computationally efficient (linear mapping, non-iterative) and does not require retraining (unlike gradient-based approaches) or retention of old raw data (unlike instance-based learning). We tested our algorithm on our rat brain Nissl data set, showing superior performance compared to an artificial neural network-based benchmark, and also demonstrated robust performance in a scenario where the data set is rapidly growing in size. Our algorithm is also highly parallelizable due to its incremental nature, and we demonstrated this empirically using a MapReduce-based implementation of the algorithm. We expect our scalable, incremental learning approach to be widely applicable to medical imaging domains where there is a constant flux of new data. © 2013 IEEE.
Original languageEnglish (US)
Title of host publicationThe 2013 International Joint Conference on Neural Networks (IJCNN)
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
ISBN (Print)9781467361293
DOIs
StatePublished - Aug 2013
Externally publishedYes

Fingerprint Dive into the research topics of 'Scalable, incremental learning with MapReduce parallelization for cell detection in high-resolution 3D microscopy data'. Together they form a unique fingerprint.

Cite this