RNAs - Physical and functional modulators of chromatin reader proteins

Kyoko Hiragami-Hamada, Wolfgang Fischle*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

The regulatory role of histone modifications with respect to the structure and function of chromatin is well known. Proteins and protein complexes establishing, erasing and binding these marks have been extensively studied. RNAs have only recently entered the picture of epigenetic regulation with the discovery of a vast number of long non-coding RNAs. Fast growing evidence suggests that such RNAs influence all aspects of histone modification biology. Here, we focus exclusively on the emerging functional interplay between RNAs and proteins that bind histone modifications. We discuss recent findings of reciprocally positive and negative regulations as well as summarize the current insights into the molecular mechanism directing these interactions. This article is part of a Special Issue entitled: Molecular mechanisms of histone modification function.

Original languageEnglish (US)
Pages (from-to)737-742
Number of pages6
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1839
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Chromodomain protein
  • Epigenetics
  • Histone modification
  • Nascent transcript
  • Non-coding RNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

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