Retrotransposons and non-protein coding RNAs

Tobias Mourier*, Eske Willerslev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Retrotransposons constitute a significant fraction of mammalian genomes. Considering the finding of widespread transcriptional activity across entire genomes, it is not surprising that retrotransposons contribute to the collective RNA pool. However, the transcriptional output from retrotransposons does not merely represent spurious transcription. We review examples of functional RNAs transcribed from retrotransposons, and address the collection of non-protein coding RNAs derived from transposable element sequences, including numerous human microRNAs and the neuronal BC RNAs. Finally, we review the emerging understanding of how retrotransposons themselves are regulated by small RNAs.

Original languageEnglish (US)
Article numberelp036
Pages (from-to)493-501
Number of pages9
JournalBriefings in Functional Genomics and Proteomics
Volume8
Issue number6
DOIs
StatePublished - Sep 3 2009

Keywords

  • Gene regulation
  • RNA genes
  • Transposable elements

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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