Responsive micelles and vesicles based on polypeptide diblock copolymers

F. Chécot, J. Rodríguez-Hernández, Yves Gnanou, S. Lecommandoux*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with a control size and shape. Results focusing on vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical application will be detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems that are able to form vesicles with narrow size distributions at basic and acidic pH going through an intermediate state of single polymer chains are presented. These nanoparticles are particularly interesting for encapsulation and delivery purposes at a controlled pH. Finally, surface self-assembly of micelles and vesicles will be shown as models for biological surfaces such as mucosal surfaces.

Original languageEnglish (US)
Pages (from-to)782-785
Number of pages4
JournalPolymers for Advanced Technologies
Volume17
Issue number9-10
DOIs
StatePublished - Sep 1 2006

Keywords

  • Block copolymers
  • Polypeptide
  • Responsive
  • Self-assembly
  • Vesicles

ASJC Scopus subject areas

  • Polymers and Plastics

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