Respiratory system impedance in patients with acute left ventricular failure: Pathophysiology and clinical interest

F. B. Depeursinge, Christian Depeursinge, A. K. Boutaleb, F. Feihl, C. H. Perret

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

To investigate the relationship between alterations in lung mechanics and acute pulmonary vascular congestion, repeated measurements of the respiratory system impedance (Z(rs)) were performed in 11 patients with and in seven without acute left ventricular failure. Indexes of Z(rs) were obtained by calculating the average and slope of the resistance and reactance in low (10 to 20 Hz) and high (20 to 50 Hz) frequency intervals. Z(rs) indexes in patients with ventricular failure differ significantly from those in patients without failure. Pulmonary vascular congestion is regularly associated with an abnormal frequency dependence of resistance at low frequencies and with an increased resonant frequency. Discriminant analysis of Z(rs) indexes allows 92% correct classification of pulmonary capillary wedge pressures lower than and those equal to or higher than 18 mm Hg. Z(rs) differences between patients with and without left ventricular failure are consistent with the presence of a small airways obstruction even in patients with mild left ventricular failure. Furthermore, use of Z(rs) indexes permits moderate and severe pulmonary vascular congestion to be distinguished from one another and this is probably due to a significant narrowing of the large airways during severe left ventricular failure.

Original languageEnglish (US)
Pages (from-to)386-395
Number of pages10
JournalCirculation
Volume73
Issue number3
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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