Removal of potentially genotoxic acetamide and arylsulfonate impurities from crude drugs by molecular imprinting

Gyorgy Szekely*, Emelie Fritz, Joao Bandarra, William Heggie, Börje Sellergren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The present study describes the synthesis and preliminary testing of molecularly imprinted polymers (MIPs) as scavenger resins for removal of the genotoxic impurities (GTI) acetamide and arylsulfonates from active pharmaceutical ingredients (API). The MIPs were synthesized as monoliths using acetamide or methyl tosylate respectively as templates. The polymers were crushed and subsequently tested in the batch and chromatographic mode for template recognition and potential removal efficiency. Both the acetamide and the tosylate MIPs exhibited a strong memory effect for their templates and selectivity with respect to model APIs. For instance the MIP for acetamide preferentially retained acetamide over other amides, such as formamide, acrylamide, methacrylamide, benzamide and N-tert-butylacrylamide. Moreover, passing model API crude contaminated with the acetamide through the MIPs led to the quantitative removal of acetamide.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalJournal of Chromatography A
Volume1240
DOIs
StatePublished - Jun 1 2012

Keywords

  • API purification
  • Genotoxic impurities
  • Molecular imprinting
  • Solid-phase extraction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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