The elastic modulus of an oral cancer cell line UM1 is investigated by nanoindentation in an atomic force microscope with a flat-ended tip. The commonly used Hertzian method gives apparent elastic modulus which increases with the loading rate, indicating strong effects of viscoelasticity. On the contrary, a rate-jump method developed for viscoelastic materials gives elastic modulus values which are independent of the rate-jump magnitude. The results show that the rate-jump method can be used as a standard protocol for measuring elastic stiffness of living cells, since the measured values are intrinsic properties of the cells. © 2011 Elsevier Ltd.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of the Mechanical Behavior of Biomedical Materials|
|State||Published - Apr 2012|
ASJC Scopus subject areas
- Biomedical Engineering
- Mechanics of Materials