Regioselective Wacker Oxidation of Internal Alkenes: Rapid Access to Functionalized Ketones Facilitated by Cross-Metathesis

Bill Morandi, Zachary K. Wickens, Robert H. Grubbs

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Wacka wacka: The title reaction makes use of a wide range of directing groups (DG) to enable the highly regioselective oxidation of alkenes, and occurs predictably at the distal position. Both E and Z alkenes afford valuable functionalized ketones and cross-metathesis was shown to facilitate the preparation of the starting materials. BQ=benzoquinone.
Original languageEnglish (US)
Pages (from-to)9933-9936
Number of pages4
JournalAngewandte Chemie
Volume125
Issue number37
DOIs
StatePublished - Jul 26 2013
Externally publishedYes

Fingerprint

Dive into the research topics of 'Regioselective Wacker Oxidation of Internal Alkenes: Rapid Access to Functionalized Ketones Facilitated by Cross-Metathesis'. Together they form a unique fingerprint.

Cite this