Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1

Fabio M V Rossi*, Stephane Y. Corbel, Jasmeen Merzaban, Douglas A. Carlow, Klaus Gossens, Jeffrey Duenas, Leslie So, Lin Yi, Hermann J. Ziltener

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

The molecular mechanisms that direct the migration of early T lymphocyte progenitors to the thymus are unknown. We show here that P-selectin is expressed by thymic endothelium and that lymphoid progenitors in bone marrow and thymus bind P-selectin. Parabiosis, competitive thymus reconstitution and short-term homing assays indicated that P-selectin and its ligand PSGL-1 are functionally important components of the thymic homing process. Accordingly, thymi of mice lacking PSGL-1 contained fewer early thymic progenitors and had increased empty niches for prothymocytes compared with wild-type mice. Furthermore, the number of resident thymic progenitors controls thymic expression of P-selectin, suggesting that regulation of P-selectin expression by a thymic 'niche occupancy sensor' may be used to direct progenitor access.

Original languageEnglish (US)
Pages (from-to)626-634
Number of pages9
JournalNature Immunology
Volume6
Issue number6
DOIs
StatePublished - Dec 8 2005

ASJC Scopus subject areas

  • Immunology

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