Rapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides

Nolan T. McDougal, Jan Streuff, Herschel Mukherjee, Scott C. Virgil, Brian M. Stoltz

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Herein an efficient and direct copper-catalyzed coupling of oxazoline-containing aryl bromides with electron-deficient secondary phosphine oxides is reported. The resulting tertiary phosphine oxides can be reduced to prepare a range of PHOX ligands. The presented strategy is a useful alternative to known methods for constructing PHOX derivatives.
Original languageEnglish (US)
Pages (from-to)5550-5554
Number of pages5
JournalTetrahedron Letters
Volume51
Issue number42
DOIs
StatePublished - Oct 2010
Externally publishedYes

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