Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers

Andrew P. Goodwin, Stephanie S. Lam, Jean Frechet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

A method for the preparation of heterobifunctional biodegradable dendrimers is described involving the preparation of a symmetric aliphatic ester dendrimer derived from 2,2-bis(hydroxymethyl)propanoic acid bearing a cyclic carbonate periphery, followed by opening of the carbonate moieties with a functional amine. This approach requiring no chromatographic purification steps was demonstrated with the preparation of a dendrimer bearing eight protected aldehydes and eight alkynes at its periphery.

Original languageEnglish (US)
Pages (from-to)6994-6995
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number22
DOIs
StatePublished - Jun 6 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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