Raman spectroscopy for detection of stretched DNAs on superhydrophobic surfaces

Monica Marini, Gobind Das, Rosanna La Rocca, Francesco T. Gentile, Tania Limongi, Stefania Santoriello, Alice Scarpellini, Enzo M. Di Fabrizio

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A novel approach for the study of low concentrated DNAs (60 pM) using microRaman spectroscopy is reported. A superhydrophobic substrate with array of microPillars is fabricated over which the sample was drop casted. The substrate concentrates the molecules in a very small area with higher molecular density, enabling to carry out the microRaman measurements. Two different DNAs (single strand and double strand) were used to investigate through Raman technique. A spectral Raman difference was found to distinguish the ssDNA and dsDNAs. The approach can be of interest for a wide variety of applications ranging from biological materials interactions characterization to the biomedical field. © 2014 Elsevier B.V. All rights reserved.
Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalMicroelectronic Engineering
Volume119
DOIs
StatePublished - May 2014

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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