Protein Phosphorylation and Cellular Information Transfer: Signaling by MAP Kinase Cascades

Claudia Jonak*, Heribert Hirt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Living cells, unicellular organisms as well as cells of multicellular organisms, are permanently exposed to a multitude of signals. Cells have to transform these external stimuli into physiological intelligible signals that are transduced from outside of the cell into the cell to induce a proper cellular response. Extracellular stimuli are perceived and internalised by various cellular receptors. Subsequently, signals are transduced by one of many protein kinase signaling cascades. Mitogen-activated protein kinases (MAPKs) belong to the evolutionary most conserved class of such molecular switches. MAPKs can change the activity of target proteins and thereby bring about physiological responses to external signals. This review discusses the basic principles of MAPK pathways in the context of cellular information processing: Cellular bioinformatics is an increasingly important interdisciplinary field with important implications for basic and applied sciences.

Original languageEnglish (US)
Pages (from-to)1481-1487
Number of pages7
JournalMonatshefte fur Chemie
Volume134
Issue number11
DOIs
StatePublished - Nov 1 2003

Keywords

  • Mitogen-activated protein kinase
  • Protein phosphorylation
  • Signal transduction

ASJC Scopus subject areas

  • Chemistry(all)

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