Processing of the hemagglutinin of influenza virus expressed in insect cells by a baculovirus vector

Kazumichi Kuroda, Charlotte Hauser, Rudolf Rott, Walter Doerfler, Hans Dieter Klenk

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Like other integral membrane proteins, the hemagglutinin (HA) as the major glycoprotein of the influenza virus envelope is translated at the rough endoplasmic reticulum and transported from there through the Golgi apparatus to the plasma membrane. In the course of transport, the HA undergoes posttranslational modifications, including removal of the signal peptide, attachment of N-glycosidic oligosaccharide side chains, acylation, and posttranslational proteolytic cleavage of the precursor HA into the fragments HA1 and HA2, which is necessary for the realization of the fusion activity.

Original languageEnglish (US)
Title of host publicationInvertebrate Cell System Applications
Subtitle of host publicationVolume I
PublisherCRC Press
Pages221-230
Number of pages10
ISBN (Electronic)9781351082297
ISBN (Print)0849343739, 9781315894744
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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