Probing Chromatin-modifying Enzymes with Chemical Tools

Wolfgang Fischle, Dirk Schwarzer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Chromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.
Original languageEnglish (US)
Pages (from-to)689-705
Number of pages17
JournalACS Chemical Biology
Volume11
Issue number3
DOIs
StatePublished - Feb 4 2016

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