Preparation of porous hydrophilic monoliths: effect of the polymerization conditions on the porous properties of poly (acrylamide-co-N,N′-methylenebisacrylamide) monolithic rods

Shaofeng Xie*, Frantisek Svec, Jean Frechet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

Molded macroporous monoliths with pores sizes up to 1000 nm have been prepared by copolymerization of the hydrophilic monomers, acrylamide, and N,N′-methylenebisacrylamide, in the presence of a porogenic diluent. A combination of dimethylsulfoxide and 2-heptanol was selected from a broad spectrum of solvents and water soluble polymers to achieve the optimum composition of the porogenic mixture. In addition to the composition of the porogen the porous properties of the monolithic rods can also be optimized through changes in the percentage of both N,N′-methylenebisacrylamide (crosslinking monomer) and azobisisobutyronitrile (free radical initiator) used for the polymerization. The hydrophilic monoliths may be used in the separation of biological polymers, solid-phase extraction, or for immobilization of proteins.

Original languageEnglish (US)
Pages (from-to)1013-1021
Number of pages9
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume35
Issue number6
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics

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