Molded macroporous monoliths with pores sizes up to 1000 nm have been prepared by copolymerization of the hydrophilic monomers, acrylamide, and N,N′-methylenebisacrylamide, in the presence of a porogenic diluent. A combination of dimethylsulfoxide and 2-heptanol was selected from a broad spectrum of solvents and water soluble polymers to achieve the optimum composition of the porogenic mixture. In addition to the composition of the porogen the porous properties of the monolithic rods can also be optimized through changes in the percentage of both N,N′-methylenebisacrylamide (crosslinking monomer) and azobisisobutyronitrile (free radical initiator) used for the polymerization. The hydrophilic monoliths may be used in the separation of biological polymers, solid-phase extraction, or for immobilization of proteins.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Polymer Science, Part A: Polymer Chemistry|
|State||Published - Jan 1 1997|
ASJC Scopus subject areas
- Materials Chemistry
- Polymers and Plastics