Practical and General Palladium-Catalyzed Synthesis of Ketones from Internal Olefins

Bill Morandi, Zachary K. Wickens, Robert H. Grubbs

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Make it simple! A convenient and general palladium-catalyzed oxidation of internal olefins to ketones is reported. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed-oil derivatives and a bioactive natural product (see scheme) are described, as well as intriguing mechanistic features.
Original languageEnglish (US)
Pages (from-to)3016-3020
Number of pages5
JournalAngewandte Chemie
Volume125
Issue number10
DOIs
StatePublished - Jan 16 2013
Externally publishedYes

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