Potentiation of apomorphine-induced climbing behaviour in mice by d-LSD

Jean Yves Sovilla*, Pierre Magistretti, Michel Schorderet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. The climbing behaviour in mice was used for studying possible interaction(s) of d-LSD with dopamine receptors. 2. 2. Doses of d-LSD ranging from 0,25 to 2,5 mg/kg injected intra-peritoneally constantly inhibited the climbing behaviour. 3. 3. In contrast, when similar doses of d-LSD were injected 10 min before apomorphine (5 mg/kg), a constant potentiation of the apomorphine-induced climbing was observed. 4. 4. Subsequent experiments performed with a neuroleptic (haloperidol) or a serotonin precursor (5-OH-tryptophan) compared to those of d-LSD with and without apomorphine would indicate that d-LSD alone displays typical serotoninergic syndrome (including inhibition of the climbing), whereas in the presence of apomorphine, an interaction at presynaptic receptors may possibly modulate dopaminergic activity.

Original languageEnglish (US)
Pages (from-to)503-511
Number of pages9
JournalProgress in Neuro-Psychopharmacology
Volume3
Issue number5-6
DOIs
StatePublished - Jan 1 1979

Keywords

  • apomorphine
  • climbing behaviour
  • d-LSD
  • dopamine receptors
  • serotonin
  • striatum

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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