Post-translational modulation of pluripotency

Ning Cai, Mo Li, Jing Qu, Guang Hui Liu*, Juan Carlos Izpisua Belmonte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalJournal of Molecular Cell Biology
Volume4
Issue number4
DOIs
StatePublished - Aug 1 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint

Dive into the research topics of 'Post-translational modulation of pluripotency'. Together they form a unique fingerprint.

Cite this