Post-Translational Modification, Phase Separation, and Robust Gene Transcription

Hari R. Singh, Yogesh B. Ostwal

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A few recent reports reveal fundamental new insights into the intricate regulatory mechanisms that govern RNA polymerase II (Pol II)-mediated gene transcription. Whereas a histidine-rich domain (HRD) triggers phase separation, promoting transcription elongation, a phosphatase switch promotes transcription termination. A paradigm that might govern the underlying mechanisms leading to robust gene transcription is now starting to emerge.
Original languageEnglish (US)
Pages (from-to)89-92
Number of pages4
JournalTrends in Genetics
Volume35
Issue number2
DOIs
StatePublished - Nov 23 2018

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