Porous polymer monoliths: Simple and efficient mixers prepared by direct polymerization in the channels of microfluidic chips

Thomas Rohr, Cong Yu, Mark H. Davey, Frantisek Svec, Jean M J Fréchet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

Porous monolithic polymers have been prepared by photoinitiated polymerization of mixtures consisting of 2-hydroxyethyl methacrylate, ethylene dimethacrylate, UV-sensitive free radical initiator and porogenic solvent within channels of specifically designed microfluidic chips and used as micromixers. Substituting azobisisobutyronitrile with 2,2-dimethoxy-2-phenylacetophenone considerably accelerated the kinetics of the polymerization. Mixtures of cyclohexanol and 1-dodecanol and of hexane and methanol were used, respectively, to control the porous properties and therefore the mixing efficiency of the device. The performance of the monolithic mixers has been tested by pumping aqueous solutions of two fluorescent dyes at various flow rates and monitoring the point at which the boundary of both streams completely disappears. Best results were achieved with a monolithic mixer containing very large irregular pores.

Original languageEnglish (US)
Pages (from-to)3959-3967
Number of pages9
JournalElectrophoresis
Volume22
Issue number18
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Microchip
  • Microfluids
  • Mixer
  • Monolith
  • Porous polymer

ASJC Scopus subject areas

  • Clinical Biochemistry

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