POPS: A fast algorithm for solvent accessible surface areas at atomic and residue level

Luigi Cavallo, Jens Kleinjung, Franca Fraternali*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

174 Scopus citations

Abstract

POPS (Parameter OPtimsed Surfaces) is a new method to calculate solvent accessible surface areas, which is based on an empirically parameterisable analytical formula and fast to compute. Atomic and residue areas (the latter represented by a single sphere centered on the Cα atom of amino acids and at the P atom of nucleotides) have been optimised versus accurate all-atom methods. The parameterisation has been derived from a selected dataset of proteins and nucleic acids of different sizes and topologies. The residue based approach POPS-R, has been devised as a useful tool for the analysis of large macromolecular assemblies like the ribosome and it is specially suited for the refinement of low resolution structures. POPS-R also allows for estimates of the loss of free energy of solvation upon complex formation, which should be particularly useful for the design of new protein - protein and protein - nucleic acid complexes. The program POPS is available at http://mathbio.nimr.mrc.ac.uk/~ffranca/ POPS and at the mirror site http://www.cs.vu.nl/~ibivu/programs/popswww.

Original languageEnglish (US)
Pages (from-to)3364-3366
Number of pages3
JournalNucleic acids research
Volume31
Issue number13
DOIs
StatePublished - Jul 1 2003

ASJC Scopus subject areas

  • Genetics

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