Polymer- versus Silica-Based Separation Media: Elimination of Nonspecific Interactions in the Chiral Recognition Process through Functional Polymer Design

Yuelong Liu, Frantisek Svec, Jean Frechet*, Kathy N. Juneau

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A novel chiral stationary phase that contains a new chiral selector based on L-valine-3,5-dimethylanilide attached to monodisperse poly(glycidyl methacrylate-co-ethylene dimethacrylate) beads has been prepared. The polymeric separation medium provides greatly enhanced enantioselectivities and reduced retention times when compared to me analogous silica-based chiral stationary phase in the separation of the enantiomers of 3,5-dinitrobenzamido derivatives of α-amino acids under normal-phase HPLC conditions. Separation factors (α) of up to 7 were achieved with the polymeric separation medium, which is also useful for the separation of large samples under overload conditions.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalAnalytical Chemistry
Volume69
Issue number1
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Analytical Chemistry

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