A membrane manufacture method based on non-volatile solvents and a high performance polymer, poly (ether imide sulfone) (EXTEM™), is proposed, as greener alternative to currently industrial process. We dissolved EXTEM™ in pure ionic liquids: 1-ethyl-3-methylimidalzolium thiocyanate ([EMIM]SCN), 1-butyl-3-methylimidalzolium thiocyanate ([BMIM]SCN), and 1-ethyl-3-methylimidalzolium acetate ([EMIM]OAc). The following polymer solution parameters were evaluated to optimize the manufacture: Gibbs free energy of mixing (G), intrinsic viscosity () and hydrodynamic diameter. Membranes with sponge-like structure and narrow pore size distribution were obtained from solutions in [EMIM]SCN. They were tested for separation of proteins and deoxyribonucleic acids (DNA). Due to the polymer stability, we foresee that applications in more demanding chemical separations would be possible. [EMIM]SCN was 96 % purified and recovered after the membrane fabrication, contributing to the sustainability of the whole manufacturing process.