Poly(DL-lactide)-b-poly(N,N-dimethylamino-2-ethyl methacrylate): Synthesis, characterization, micellization behavior in aqueous solutions, and encapsulation of the hydrophobic drug dipyridamole

Nikos Karanikolopoulos, Miljana Zamurovic, Marinos Pitsikalis*, Nikolaos Hadjichristidis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

We synthesized a series of well-defined poly(DL-lactide)-b-poly(N,N- dimethylamino-2-ethyl methacrylate) (PDLLAb-PDMAEMA) amphiphilic diblock copolymers by employing a three-step procedure: (a) ring-opening polymerization (ROP) of DL-lactide using n-decanol and stannous octoate, Sn(Oct)2, as the initiating system, (b) reaction of the PDLLA hydroxyl end groups with bromoisobutyryl bromide, and (c) atom transfer radical polymerization, ATRP, of DMAEMA with the newly created bromoisobutyryl initiating site. The aggregation behavior of the prepared block copolymers was investigated by dynamic light scattering and ζ potential measurements at 25 °C in aqueous solutions of different pH values. The hydrophobic drug dipyridamole was efficiently incorporated into the copolymer aggregates in aqueous solutions of pH 7.40. High partition coefficient values were determined by fluorescence spectroscopy.

Original languageEnglish (US)
Pages (from-to)430-438
Number of pages9
JournalBiomacromolecules
Volume11
Issue number2
DOIs
StatePublished - Feb 8 2010

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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