Polycomb, epigenomes, and control of cell identity

Valerio Orlando*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

276 Scopus citations

Abstract

In development, cell identity is maintained by epigenetic functions that prevent changes in cell type-specific transcription programs. Recent insights into gene silencing mechanisms by Polycomb group (PcG) and trithorax group (trxG) proteins reveal that the memory system involves a concerted process of chromatin modification, blocking of RNA polymerase II, and synthesis of noncoding RNA. Remarkably, cell memory is regulated by a balance between repressors and activators that maintains both transcription status and at the same time the possibility of switching to a different state.

Original languageEnglish (US)
Pages (from-to)599-606
Number of pages8
JournalCell
Volume112
Issue number5
DOIs
StatePublished - Mar 7 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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