Polycomb complex recruitment in pluripotent stem cells

Maria J. Barrero*, Juan Carlos Izpisua Belmonte

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of methylated H3K27 found at target sites occupied by the PRC2 component. However, mounting evidence suggests that PRC2-independent mechanisms of PRC1 recruitment exist. Three studies describe that the histone demethylase Kdm2b binds to unmethylated CpG islands and recruits a subset of PRC1 complexes to chromatin in pluripotent stem cells.

Original languageEnglish (US)
Pages (from-to)348-350
Number of pages3
JournalNature Cell Biology
Volume15
Issue number4
DOIs
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Cell Biology

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