Polarity-directed one-pot asymmetric cascade reactions mediated by two catalysts in an aqueous buffer

Steven T. Scroggins, Yonggui Chi, Jean Frechet

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

(Figure Presented) A crossing between phases: Polarity makes a difference in distinguishing substrates of otherwise nearly identical chemical reactivities. A one-pot cascade reaction involving nitromethane and two aliphatic aldehydes with similar reactivities has been developed (see scheme). The use of a biphasic reaction medium with two different organic catalysts results in the controlled incorporation of both aldehyde substrates into a single major cross-product.

Original languageEnglish (US)
Pages (from-to)2393-2396
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number13
DOIs
StatePublished - Mar 22 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Polarity-directed one-pot asymmetric cascade reactions mediated by two catalysts in an aqueous buffer'. Together they form a unique fingerprint.

Cite this