Plasmonic nanostructures for the ultrasensitive detection of biomolecules

G. Das, M. L. Coluccio, S. Alrasheed, A. Giugni, M. Allione, B. Torre, G. Perozziello, P. Candeloro, E. Di Fabrizio*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The central physical phenomenon described in this paper is the optical generation of surface plasmon polaritons within different kinds of nanostructures. It determines the local enhancement of the incident and scattered electromagnetic field by nearby molecules. The paper reviews different plasmonic devices whose design and spatial arrangement offer an optimal detection level of biomolecules when combined with Raman spectroscopy or hot electrons imaging. Recent results, obtained by the authors, demonstrated that it is possible to reach an analytical sensitivity in the attomolar concentration range, with an analytical specificity to solve complex peptide mixtures characterized by single point mutation in cancer detection experiments. In a different context, exploiting the adiabatic compression phenomenon, we have reported the possibility to generate both light and hot electrons sources in a localized area of few nanometers. Their energy control and accurate spatial localization allow the investigation of matter with unprecedented accuracy and richness of information.

Original languageEnglish
Pages (from-to)547-586
Number of pages40
JournalLa Rivista del Nuovo Cimento
Volume39
Issue number11
DOIs
StatePublished - Nov 2016

Keywords

  • ENHANCED RAMAN-SCATTERING
  • SINGLE-MOLECULE DETECTION
  • DEGENERATE ELECTRON-GAS
  • SURFACE-PLASMON
  • COLLECTIVE DESCRIPTION
  • SILVER ELECTRODE
  • SERS
  • SPECTROSCOPY
  • RESONANCE
  • NANOPARTICLES

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