Plasma membrane-associated platforms: Dynamic scaffolds that organize membrane-associated events

Veronica Astro, Ivan De Curtis

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Specialized regions of the plasma membrane dedicated to diverse cellular processes, such as vesicle exocytosis, extracellular matrix remodeling, and cell migration, share a few cytosolic scaffold proteins that associate to form large plasma membrane-associated platforms (PMAPs). PMAPs organize signaling events and trafficking of membranes and molecules at specific membrane domains. On the basis of the intrinsic disorder of the proteins constituting the core of these PMAPs and of the dynamics of these structures at the periphery of motile cells, we propose a working model for the assembly and turnover of these platforms.
Original languageEnglish (US)
JournalScience Signaling
Volume8
Issue number367
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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