Phylogenetic subtypes of human T-lymphotropic virus type I and their relations to the anthropological background

Tomoyuki Miura, Takuya Fukunaga, Tatsuhiko Igarashi, Masahiro Yamashita, Eiji Ido, Shin Ichi Funahashi, Takafumi Ishida, Keiko Washio, Shintarou Ueda, Ken Ichiro Hashimoto, Mitsuaki Yoshida, Mitsuhiro Osame, Bhim Sen Singhal, Vladimir Zaninovic, Luis Cartier, Shunro Sonoda, Kazuo Tajima, Yasuo Ina, Takashi Gojobori, Masanori Hayami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

157 Scopus citations

Abstract

Isolates of human T-lymphotropic virus type I(HTLV-I) were phylogenetically analyzed from native inhabitants in India and South America (Colombia and Chile) and from Ainu (regarded as pure Japanese descendants from the preagricultural 'Jomon' period). Their genomes were partially sequenced together with isolates from Gabon in central Africa and from Ghana in West Africa. The phylogenetic tree was constructed from the sequence data obtained and those of previously reported HTLV-I isolates and simian T- lymphotropic virus type I (STLV-I) isolates. The heterogeneity of HTLV-I was recently recognized, and one major type, generally called the 'cosmopolitan' type, contained Japanese, Caribbean, and West African isolates. The phylogenetic tree constructed in the present study has shown that this cosmopolitan type can be further grouped into three lineages (subtypes A, B, and C). Subtype A consists of some Caribbean, two South American, and some Japanese isolates, including that from the Ainu, in addition to an Indian isolate, and subtype B consists of other Japanese isolates in addition to another Indian isolate, suggesting that there might be at least two ancestral lineages of the Japanese HTLV-I. Subtype A implies a close connection of the Caribbean and South American natives with the Japanese and thereby a possible migration of the lineage to the American continent via Beringia in the Paleolithic era. Subtype C consists of the West African and other Caribbean isolates, indicating that not all but part of the Caribbean strains directly originated from West Africa probably during the period of slave trade. The tree also has shown that the HTLV-I isolate from Gabon in central Africa forms a cluster with STLV-I from a chimpanzee, suggesting a possible interspecies transmission between man and the chimpanzee in the past. No specific clustering was observed in the tree in relation to manifestations of the disease such as adult T-cell leukemia and HTLV-I-related neurological disorders. Thus, the topology of the phylogenetic tree reflects the movement of people carrying the virus in the past.

Original languageEnglish (US)
Pages (from-to)1124-1127
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number3
DOIs
StatePublished - Feb 1 1994

ASJC Scopus subject areas

  • General

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