Photoredox/rhodium catalysis in C–H activation for the synthesis of nitrogen containing heterocycles

Hyun Jin Kim, David C. Fabry, Steffen Mader, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The cyclization of acetanilides with alkyne derivatives has been accomplished via a direct C–H functionalization/cyclization pathway in the presence of a photoredox catalyst. The combination of a readily available Rh(III) and photoredox catalyst under irradiation with 11 W CFL afforded not only indoles but also pyrrole derivatives in good yields. Mechanistic studies provide evidence for the independent role of each catalyst. In addition, a similar efficiency of the cyclization reaction was achieved with a heterogeneous photoredox catalyst.
Original languageEnglish (US)
Pages (from-to)2319-2323
Number of pages5
JournalOrganic Chemistry Frontiers
Volume6
Issue number14
DOIs
StatePublished - 2019

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