Photoredox-Catalyzed Ketyl–Olefin Coupling for the Synthesis of Substituted Chromanols

Eleonora Fava, Masaki Nakajima, Anh L. P. Nguyen, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

A visible light photoredox-catalyzed aldehyde olefin cyclization is reported. The method represents a formal hydroacylation of alkenes and alkynes and provides chromanol derivatives in good yields. The protocol takes advantage of the double role played by trialkylamines (NR3) which act as (i) electron donors for reducing the catalyst and (ii) proton donors to activate the substrate via a proton-coupled electron transfer. © 2016 American Chemical Society.
Original languageEnglish (US)
Pages (from-to)6959-6964
Number of pages6
JournalThe Journal of Organic Chemistry
Volume81
Issue number16
DOIs
StatePublished - Jul 21 2016

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