Photodetection of early cancer by laser induced fluorescence of a tumor-selective dye. Apparatus design and realization

G. Wagnieres*, Ch Depeursinge, Ph Monnier, M. Savary, P. Cornaz, A. Chatelain, H. van den Bergh

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

26 Scopus citations

Abstract

An apparatus is designed and realized to detect 'early' cancer at the surface of the hollow organs in the human body by endoscopic means. The tumor is localized by the laser induced fluorescence of a dye (HPD) which concentrates selectively in the neoplastic tissue after intravenous injection. Fluorescence contrast between the tumor and its normal surroundings is enhanced by subtracting the background autofluorescence which occurs in both types of tissue. This is done by means of 2-color digital images manipulation in real-time. Preliminary clinical tests of the apparatus demonstrated the detection of carcinoma in situ in the esophagus.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Int Soc for Optical Engineering
Pages43-52
Number of pages10
ISBN (Print)0819402443, 9780819402448
DOIs
StatePublished - Jan 1 1990
EventProceedings of Photodynamic Therapy: Mechanisms II - Los Angeles, CA, USA
Duration: Jan 16 1990Jan 17 1990

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1203
ISSN (Print)0277-786X

Other

OtherProceedings of Photodynamic Therapy: Mechanisms II
CityLos Angeles, CA, USA
Period01/16/9001/17/90

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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