Phase equilibria in ternary mixtures of the ionic liquid bmim[BF 4], (S)-naproxen and CO2 to determine optimum regions for green processing

Eliane Kühne, Sabrina Santarossa, Geert Jan Witkamp, Cor J. Peters

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

In order to optimize reaction and separation processes, knowledge of the phase behaviour of the system is of fundamental importance. In this contribution we present the solid-liquid and liquid-vapour equilibria of the ternary system 1-butyl-3-methylimidazolium tetrafluoroborate + (S)-naproxen + carbon dioxide. Five different samples were studied, with CO2 concentrations ranging from 10 to 50 mol%, and pressure and temperature conditions of 1 to 14 MPa, and 310 to 370 K, respectively. It is shown that the amount of CO2 influences not only the location of the homogeneous liquid phase region, but also the extension of the region in which it occurs. Based on the collected experimental data, optimum pressure and temperature conditions can be selected for the precipitation of (S)-naproxen from the ionic liquid in order to improve the efficiency of the separation.

Original languageEnglish (US)
Pages (from-to)762-766
Number of pages5
JournalGreen Chemistry
Volume10
Issue number7
DOIs
StatePublished - Jul 8 2008
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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