Pharmacological potential of cerium oxide nanoparticles

Ivana Celardo, Jens Z. Pedersen, Enrico Traversa, Lina Ghibelli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

573 Scopus citations

Abstract

Nanotechnology promises a revolution in pharmacology to improve or create ex novo therapies. Cerium oxide nanoparticles (nanoceria), well-known as catalysts, possess an astonishing pharmacological potential due to their antioxidant properties, deriving from a fraction of Ce3+ ions present in CeO2. These defects, compensated by oxygen vacancies, are enriched at the surface and therefore in nanosized particles. Reactions involving redox cycles between the Ce3+ and Ce4+ oxidation states allow nanoceria to react catalytically with superoxide and hydrogen peroxide, mimicking the behavior of two key antioxidant enzymes, superoxide dismutase and catalase, potentially abating all noxious intracellular reactive oxygen species (ROS) via a self-regenerating mechanism. Hence nanoceria, apparently well tolerated by the organism, might fight chronic inflammation and the pathologies associated with oxidative stress, which include cancer and neurodegeneration. Here we review the biological effects of nanoceria as they emerge from in vitro and in vivo studies, considering biocompatibility and the peculiar antioxidant mechanisms.

Original languageEnglish (US)
Pages (from-to)1411-1420
Number of pages10
JournalNanoscale
Volume3
Issue number4
DOIs
StatePublished - Apr 1 2011

ASJC Scopus subject areas

  • Materials Science(all)

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