PH responsive self-assembly of cucurbit[7]urils and polystyrene-block- polyvinylpyridine micelles for hydrophobic drug delivery

Basem Moosa, Afnan Mashat, Wengang Li, Karim Fhayli, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Polystyrene-block-polyvinylpyridine (PS-b-P4VP) polypseudorotaxanes with cucurbit[7]urils (CB[7]) were prepared from water soluble PS-b-P4VPH+ polymer and CB[7] in aqueous solution at room temperature. At acidic and neutral pH, the pyridinium block of PS-b-P4VP is protonated (PS-b-P4VPH +) pushing CB[7] to preferably host the P4VP block. At basic pH (pH 8), P4VP is not charged and thus is not able to strongly complex CB[7]. This phenomenon was verified further by monitoring the release of pyrene, a hydrophobic cargo model, from a PS-b-P4VPH+/CB[7] micellar membrane. Release study of UV active pyrene from the membrane at different pH values revealed that the system is only operational under basic conditions and that the host-guest interaction of CB[7] with P4VPH+ significantly slows down cargo release.
Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Nanomaterials
Volume2013
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Materials Science(all)

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