Peroxisomes: Organization and Transport in Neurons

Naganand Rayapuram*, S. Subramani

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Peroxisomes are ubiquitous, single-membrane enclosed organelles found in most eukaryotes. In humans, they are abundant in the brain, heart, kidney, and liver. They house enzymes involved in many lipid metabolic pathways, such as the oxidation of very long-chain fatty acids, bile acid intermediates, 2- and 3-methyl-branched fatty acids, and. l-pipecolic acid, as well as in plasmalogen synthesis. The importance of this organelle is emphasized by the fact that peroxisome biogenesis is essential for survival in mammals. Interestingly, many of the human peroxisome biogenesis disorders present as neurological problems, and among the many symptoms observed is a neuronal migration defect. This article provides a brief summary of the role of peroxisomes in neurons, their mode of movement in mammals, and diseases associated with defects in neuronal migration.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages589-594
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Dynein
  • Kinesin
  • Microtubule-associated movement
  • Neuronal migration
  • Peroxisome biogenesis disorders
  • Peroxisome motility
  • Peroxisomes
  • Zellweger syndrome

ASJC Scopus subject areas

  • Neuroscience(all)

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