Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for Three-Dimensional Organotypic Cultures

Yihua Loo, Anupama Lakshmanan, Ming Ni, Lai Ling Toh, Shi Wang, Charlotte A E Hauser*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

Printable scaffolds with adequate mechanical strength and stiffness are sought after to ensure viability of printed cells and tissues. We report the first peptide bioinks-lysine-containing hexapeptides that self-assemble into stable, nanofibrous three-dimensional hydrogels with unprecedented stiffness of up to 40 kPa. These biocompatible scaffolds support the three-dimensional culture of human stem cells and differentiation of primary cells into organotypic (gastrointestinal and skin) structures for high-throughput screening, diagnosis, and tissue engineering.

Original languageEnglish (US)
Pages (from-to)6919-6925
Number of pages7
JournalNano Letters
Volume15
Issue number10
DOIs
StatePublished - Oct 14 2015
Externally publishedYes

Keywords

  • bioprinting
  • nanofibrous scaffold
  • Peptide bioink
  • smart biomaterials
  • stimuli-responsive self-assembly
  • ultrashort peptides

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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