Penetration of living cell membranes with fortified carbon nanotube tips

Ivan Uriev Vakarelski, Scott C. Brown, Ko Higashitani, Brij M. Moudgil*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

We have fabricated robust nanosurgical needles suitable for single cell operations by modifying multiwalled carbon nanotube (MCNT)-terminated atomic force microscopy (AFM) tips. Extra-long MCNT AFM tips were prepared and fortified with molecular layers of carbon to overcome mechanical instabilities and then coated with an outer shell of gold to promote chemical versatility. The terminal diameters of the final fabricated tips were approximately 30-40 nm, and the MCNT probes were several micrometers in length. We illustrate the capability of these modified MCNT tips to carry nanoparticulate payloads and to penetrate the plasma membrane of living pleural mesothelial cells at the smallest indentation depths (100-200 nm) and lowest penetration forces (100-200 pN) currently reported for these procedures.

Original languageEnglish (US)
Pages (from-to)10893-10896
Number of pages4
JournalLangmuir
Volume23
Issue number22
DOIs
StatePublished - Oct 23 2007

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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