[PdA (IPr*) (cinnamyl)Cl]: An efficient pre-catalyst for the preparation of tetra-ortho-substituted biaryls by Suzuki-Miyaura cross-coupling

Anthony Chartoire, Mathieu Lesieur, Laura Falivene, Alexandra M. Z. Slawin, Luigi Cavallo, Catherine S. J. Cazin, Steven P. Nolan

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

The bigger the better: The new well-defined [Pd(IPr*)(cin)Cl] pre-catalyst is described (see scheme). This complex proves to be highly active in the Suzuki-Miyaura cross-coupling for the synthesis of tetra-ortho- substituted biaryls under mild conditions. IPr* is reported as the largest N-heterocyclic carbene (NHC) to date for [Pd(NHC)(cin)Cl] complexes, explaining the high reactivity observed for this complex in this challenging transformation. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish (US)
Pages (from-to)4517-4521
Number of pages5
JournalChemistry - A European Journal
Volume18
Issue number15
DOIs
StatePublished - Mar 13 2012

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of '[PdA (IPr*) (cinnamyl)Cl]: An efficient pre-catalyst for the preparation of tetra-ortho-substituted biaryls by Suzuki-Miyaura cross-coupling'. Together they form a unique fingerprint.

Cite this