Particulate drug delivery systems for P/M medical combination devices

G. Dawes, L. E. Fratila-Apachitei, I. Apachitei, G. J. Witkamp, J. Duszczyk

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

P/M technology is used in orthopedic implants to create porous surfaces for bone ingrowth. However, these porous surfaces can be exploited for the storage of biofunctional particles in order to generate multifunctional surfaces needed to fight against peri-implant infection or enhance osseointegration. The morphology and release kinetics of several drug delivery systems combining poly(lactide-co-glycolide) particles with porous metallic surfaces were compared to investigate their use for P/M medical combination devices. The drug loaded poly(lactide-co-glycolide) microparticles were produced by an oil-in-water emulsion/solvent evaporation method. The larger particles (26±10 μm) showed a triphasic drug release profile regardless of the type of surface they were attached to, and a sustained release could be achieved for at least 650 hours. The smaller particles (0.6±0.3 μm) attached to a surface having a pore size of 1.1±0.3 μm showed only burst release kinetics of the encapsulated drug. The applications of such systems for porous surfaces obtained by P/M technology are discussed.

Original languageEnglish (US)
Title of host publicationProceedings of the Euro International Powder Metallurgy Congress and Exhibition, Euro PM 2009
PublisherEuropean Powder Metallurgy Association (EPMA)
Volume2
ISBN (Print)9781899072088
StatePublished - Jan 1 2009
Externally publishedYes
EventEuropean International Powder Metallurgy Congress and Exhibition, Euro PM 2009 - Copenhagen, Denmark
Duration: Oct 12 2009Oct 14 2009

Conference

ConferenceEuropean International Powder Metallurgy Congress and Exhibition, Euro PM 2009
CountryDenmark
CityCopenhagen
Period10/12/0910/14/09

ASJC Scopus subject areas

  • Mechanics of Materials
  • Ceramics and Composites
  • Materials Chemistry
  • Metals and Alloys
  • Condensed Matter Physics

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